کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
20129 43159 2016 5 صفحه PDF ندارد دانلود کنید
عنوان انگلیسی مقاله
Cryptic antifungal compounds active by synergism with polyene antibiotics
ترجمه فارسی عنوان
ترکیبات ضد قارچی مرموز فعال توسط سینرژیسم با آنتی بیوتیک polyene
کلمات کلیدی
ترکیبات ضد قارچ؛ آنتی بیوتیک های پلی آن اسید هلوولیک؛ Terramide A؛ قارچ های Entomopathogenic
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی

The majority of antifungal compounds reported so far target the cell wall or cell membrane of fungi, suggesting that other types of antibiotics cannot exert their activity because they cannot penetrate into the cells. Therefore, if the permeability of the cell membrane could be enhanced, many antibiotics might be found to have antifungal activity. We here used the polyene antibiotic nystatin, which binds to ergosterol and forms pores at the cell membrane, to enhance the cellular permeability. In the presence of nystatin, many culture extracts from entomopathogenic fungi displayed antifungal activity. Among all the active extracts, two active components were purified and identified as helvolic acid and terramide A. Because the minimum inhibitory concentration of either compound was reduced four-fold in the presence of nystatin, it can be concluded that this screening method is useful for detecting novel antifungal activity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Bioscience and Bioengineering - Volume 121, Issue 4, April 2016, Pages 394–398
نویسندگان
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