کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2031832 1542799 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Polymorphisms in the type I deiodinase gene and frontal function in recurrent depressive disorder
ترجمه فارسی عنوان
پلی مورفیسم ها در ژن deiodinase نوع یک و عملکرد فرونتال در اختلال افسردگی راجعه
کلمات کلیدی
deiodinase نوع یک ؛ پلی مورفیسم؛ عملکردهای شناختی؛ اختلال افسردگی راجعه
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
چکیده انگلیسی

PurposeSignificant impairment of some psychological functions, including cognitive functioning, has been characteristically found in depressed patients. Memory disturbances may be related to the levels of thyroid hormones (TH) that are under the influence of different mechanisms and molecules, including deiodinase type 1(D1) – an important determinant of circulating triiodothyronine (T3). We investigated the relationship between two functionally known polymorphisms within the DIO1 gene, i.e. DIO1a-C/T and DIO1b-A/G, and cognitive functioning in patients diagnosed with recurrent depressive disorder (rDD). In the planned analysis we mainly concentrated on the frontal function: working memory, executive functions and verbal fluency.Materials and methodsGenetic variants were genotyped in 128 patients using a method based on polymerase chain reaction (PCR). Cognitive functions were assessed by the Trail Making Test, the Stroop Test and the Verbal Fluency Test (VFT).ResultsNo significant associations were found between DIO1 polymorphisms and cognitive functioning in rDD. Only the CT and TT genotypes of the DIO1a variant were significantly related to verbal fluency. There were no significant differences between the distribution of the genotypes and demographic/medical variables.ConclusionsBased on the study, the examined polymorphisms are not an important risk or protective factor for cognitive impairment in depressive patients. Functional variants within the DIO1 gene that affect triiodothyronine (T3) levels seem not to be associated with cognitive functions. Nevertheless, considering the fact that the DIO1 gene is related to the course and management of depression, further studies on a larger sample size might be suggested.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Advances in Medical Sciences - Volume 61, Issue 2, September 2016, Pages 198–202
نویسندگان
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