کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2032369 1542862 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Anti-infective, cytotoxic and antioxidant activity of Ziziphus oxyphylla and Cedrela serrata
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
Anti-infective, cytotoxic and antioxidant activity of Ziziphus oxyphylla and Cedrela serrata
چکیده انگلیسی

ObjectiveTo search for the most active antimicrobial and antioxidant sub-fractions related to traditional use of Ziziphus oxyphylla (Z. oxyphylla) and Cedrela serrata (C. serrata) in Pakistan against infectious and liver diseases.MethodsFactions of different polarity were tested in vitro for their antiprotozoal, antimalarial, antibacterial and antifungal activity against different pathogens. Cytotoxicity on MRC-5 cell lines (human lung fibroblasts) as well as, in vitro radical scavenging activity was evaluated using the 1, 1-diphenyl-2-picrylhydrazyl radical assay.ResultsThe highest antiprotozoal activity was observed for the CHCl3 fractions of Z. oxyphylla roots and leaves, and C. serrata bark. The CHCl3 and EtOAc fractions of Z. oxyphylla roots, the CHCl3 fraction of Z. oxyphylla leaves, the EtOAc and the residual MeOH: H2O fraction of C. serrata bark showed antibacterial activity against Staphylococcus aureus. The same residual MeOH: H2O fraction of C. serrata bark was active against Candida albicans. The highest antioxidant activity was observed for the more hydrophilic EtOAc fractions of Z. oxyphylla leaves, C. serrata bark and leaves, and the residual MeOH: H2O fraction of C. serrata bark.ConclusionsThis study supports at least in part the traditional uses of these plants for antimicrobial purposes and against liver diseases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Asian Pacific Journal of Tropical Biomedicine - Volume 6, Issue 8, August 2016, Pages 671–676
نویسندگان
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