کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2034868 1072107 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Modulation of bone morphogenetic protein antagonists to stimulate clinical osteogenesis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
Modulation of bone morphogenetic protein antagonists to stimulate clinical osteogenesis
چکیده انگلیسی

Bone morphogenetic proteins (BMPs) are important for the development and functioning of a wide variety of tissues and organ systems. Their ability to induce bone formation has been harnessed for clinical application. Specifically, local application of BMPs into fractures and fusions has shown some efficacy in inducing bone formation. However, clinical success has not been as robust as might be expected from the results obtained using animal models. This difference may be due to a number of mechanisms regulating BMP activity in vivo. One class of major regulators is the extracellular antagonist (e.g. Noggin, Gremlin, DAN), the dysfunction of which has been shown to result in ectopic bone formation in animal models and human disease. We hypothesize that local application of BMPs at high concentrations induces increased production of BMP antagonists, thereby limiting BMP activity and clinical efficacy. Therapies blocking the function of BMP antagonists should therefore result in enhanced BMP activity and increased bone formation. Furthermore, titrated systemic regulation of BMP antagonist may potentially reverse osteoporosis. Our collective experience with the clinical use of BMP illustrates the importance of understanding mechanisms of endogenous antagonism and regulation in the exogenous application of a protein as a therapeutic.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioscience Hypotheses - Volume 2, Issue 5, 2009, Pages 322–325
نویسندگان
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