کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2065044 1076903 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
“The King is dead”: Checkmating ion channels with tethered toxins
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
“The King is dead”: Checkmating ion channels with tethered toxins
چکیده انگلیسی

AbstRactThe quickest possible checkmate in the game of chess requires two moves using a pawn and the queen. Metaphorically speaking, the pawn (a membrane tether) and the queen (a toxin) work together to checkmate an ion channel within a neuronal circuit. This strategy termed “tethered toxin” (t-toxin) is based on the use of genetically encoded peptide toxins that are anchored to the cell-membrane via a glycolipid or transmembrane tether. Because of their mode of action at the cell surface, t-toxins act only on ion channels and receptors of the cell that is expressing the t-toxin, and not on identical receptors present in neighboring cells that do not express the t-toxin. In this mini-review we discuss the design of these genetic tools and their application for cell-specific and temporal manipulation of ion channel-mediated activities in vivo.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicon - Volume 56, Issue 8, December 2010, Pages 1293–1298
نویسندگان
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