Quasi emulsion spherical crystallization technique based environmentally responsive Tulsion® (pH dependent) microspheres for colon specific delivery

- pH-dependent sustained-release Tulsion® microspheres bearing clarithromycin.
- Quasi-emulsion solvent diffusion method applied using thermocoat L 30 D 5.
- Thermocoat L 30 D 55 used as release retardant for Tulsion® microspheres.
- Ratiometric optimization of different solvents using phase diagrams.
- Developed microspheres showed sustain release profile as well as targeting to colon.