کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
2101360 1083236 2016 3 صفحه PDF ندارد دانلود رایگان
عنوان انگلیسی مقاله
New Light Chain Amyloid Response Criteria Help Risk Stratification of Patients by Day 100 after Autologous Hematopoietic Cell Transplantation
ترجمه فارسی عنوان
معیارهای جدید واکنش آمیلوئید زنجیره سبک به طبقه بندی خطر ابتلا بیماران در 100 روز پس از پیوند سلول های خون ساز اتولوگ کمک می کند
کلمات کلیدی
زنجیره سبک (AL) آمیلوئیدوز؛ معیار های پاسخ 2012 . پاسخ پس از پیوند 100 روز
Light chain (AL) amyloidosis; 2012 response criteria; Day 100 post-transplantation response
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی


• Independent validation of the 2012 hematologic response criteria for AL amyloidosis using the CIBMTR database.
• At day 100 post-transplant, these criteria can help identify poor responders.
• Patients with less than VGPR have equally worse outcomes and should be studied further for consideration of consolidative therapy.

Hematologic response criteria in light chain (AL) amyloidosis were updated in 2012 to incorporate free light chain responses. These criteria have been validated in autologous hematopoietic cell transplantation in AL at 6 and 12 months after transplantation. Using a transplantation registry, we assessed day 100 responses in AL amyloidosis. We validate the prognostic significance of the new criteria at this time point. Further, we show that patients who do not achieve at least a very good partial response by this time point have equally worse outcomes, regardless of depth of response (partial versus no response). Thus, we conclude that the new criteria help identify the poor responders by day 100 after transplantation and that this subset of patients should be studied for early evaluation in consolidation trials.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 22, Issue 4, April 2016, Pages 768–770
نویسندگان
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