|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|2101360||1083236||2016||3 صفحه PDF||ندارد||دانلود رایگان|
• Independent validation of the 2012 hematologic response criteria for AL amyloidosis using the CIBMTR database.
• At day 100 post-transplant, these criteria can help identify poor responders.
• Patients with less than VGPR have equally worse outcomes and should be studied further for consideration of consolidative therapy.
Hematologic response criteria in light chain (AL) amyloidosis were updated in 2012 to incorporate free light chain responses. These criteria have been validated in autologous hematopoietic cell transplantation in AL at 6 and 12 months after transplantation. Using a transplantation registry, we assessed day 100 responses in AL amyloidosis. We validate the prognostic significance of the new criteria at this time point. Further, we show that patients who do not achieve at least a very good partial response by this time point have equally worse outcomes, regardless of depth of response (partial versus no response). Thus, we conclude that the new criteria help identify the poor responders by day 100 after transplantation and that this subset of patients should be studied for early evaluation in consolidation trials.
Journal: - Volume 22, Issue 4, April 2016, Pages 768–770