Outcome of pregnancy in chronic myeloid leukaemia patients treated with tyrosine kinase inhibitors: Short report from a single centre

• Positive outcome of pregnancy in CML patients on TKI treatment.
• Uneventful pregnancies whilst being on TKI from 1st trimester.
• Unique case of woman who received 5 different treatments for CML in 3 pregnancies.
• Prolonged exposure to TKI during pregnancy and breast feeding in all cases.

BackgroundThe aim of this work was to report on the outcome of pregnancy in patients with chronic myeloid leukaemia who were on tyrosine kinase inhibitor treatment.Patients and methodsWe report the result of 22 pregnancies in 14 patients (9 female and 5 male) who conceived or their partner conceived while being on tyrosine kinase inhibitors for their CML.ResultsAll pregnancies except one were uneventful. 25 newborns were born and except in one case where small atrial septal defect was diagnosed, all infants were healthy and showed normal development after birth.ConclusionThis small series does indicate that parents can most likely expect an uneventful outcome to a pregnancy despite exposure of either partner to TKIs. There is no consensus or guideline regarding the best practice in case of pregnancy. More reports of similar nature would certainly be beneficial to practitioners and patients alike. As such it is still recommended to practice effective contraception during the period of TKI treatment.