The clinical pathological significance of Thy1 and CD49f expression in chondrosarcomas

ObjectiveThis study investigated the protein expression and clinicopathological significance of Thy1 and CD49f in chondrosarcomas.MethodsThy1 and CD49f protein expression in 59 chondrosarcomas and 33 osteochondromas were measured by immunohistochemical staining.ResultsThe percentage of positive Thy1 and CD49f expression was significantly higher in patients with chondrosarcoma than in patients with osteochondroma (P < 0.01). The percentage of positive Thy1 and CD49f expression was significantly lower in patients with histological grade I, Enneking stage I, AJCC stage I/II stage, non-metastatic and non-invasive chondrosarcoma than in patients with histological grade III, Enneking stage II + III, AJCC stage III/IV, metastatic and invasive chondrosarcoma (P < 0.05 or P < 0.01). Thy1 expression was positively correlated with CD49f expression in chondrosarcoma. Kaplan-Meier survival analysis showed that histological grade, AJCC stage, Enneking stage, metastasis, invasion, and Thy1 and CD49f expression significantly correlated with shorter mean survival time in chondrosarcoma patients (P < 0.05 or P < 0.01). Cox multivariate analysis showed that positive Thy1 and CD49f expression was an independent prognostic factor that negatively correlated with overall postoperative survival.ConclusionPositive Thy1 and CD49f expression is significantly associated with the progression and poor prognosis of chondrosarcoma.