کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2165858 1549317 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Purinergic signalling-evoked intracellular Ca2+ concentration changes in the regulation of chondrogenesis and skeletal muscle formation
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Purinergic signalling-evoked intracellular Ca2+ concentration changes in the regulation of chondrogenesis and skeletal muscle formation
چکیده انگلیسی


• Precisely set intracellular Ca2+-concentration changes regulate chondrogenesis.
• Elements of purinergic signalling are expressed in immature cartilage and muscle.
• Ectopurines evoke intracellular Ca2+-events during muscle and cartilage formation.
• Various functions of chondrocytes are altered by Ca2+-concentration changes.
• Cell proliferation is very sensitive to properly set intracellular Ca2+-events

It is now widely recognised that changes of the intracellular calcium concentration have deep impact on the differentiation of various non-excitable cells including the elements of the vertebrate skeleton. It has become evident that purinergic signalling is one of the most ancient cellular mechanisms that can cause such alterations in the intracellular Ca2+-homeostasis, which are precisely set either spatially or temporally. Purinergic signalling is believed to regulate intracellular Ca2+-concentration of developing cartilage and skeletal muscle cells and suggested to play roles in the modulation of various cellular functions. This idea is supported by the fact that pluripotent mesenchymal cells, chondroprogenitors or muscle precursors, as well as mature chondrocytes all are capable of releasing ectonucleotides, and express various types of purinoreceptors and ectonucleotidases. The presence of the basic components of purinergic signalling proves that cells of the chondrogenic lineage can utilise this mechanism for modulating their intracellular Ca2+ concentration independently from the surrounding skeletal muscle and bone tissues, which are well known to release ectopurines during development and mechanical stress. In this review, we summarize accumulating experimental evidence supporting the importance of purinergic signalling in the regulation of chondrogenesis and during skeletal muscle formation.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cell Calcium - Volume 59, Issues 2–3, March 2016, Pages 108–116
نویسندگان
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