کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2167027 1092302 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Amelioration of autoimmune arthritis by naringin through modulation of T regulatory cells and Th1/Th2 cytokines
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Amelioration of autoimmune arthritis by naringin through modulation of T regulatory cells and Th1/Th2 cytokines
چکیده انگلیسی


• We investigated the effect of naringin on the key mediators of arthritic inflammation.
• We treated Balb/c mice (p.o.) with naringin (20, 40 and 80 mg/kg) or saline daily for 14 days.
• Naringin-treated mice demonstrated a considerable decrease in the level of T cell subsets.
• Naringin treatment resulted in significantly upregulated Treg and Th2 cytokine levels.
• Naringin-induced inhibition of the various pro-inflammatory and inflammatory mediators.

Naringin, a well-known flavanone glycoside found in grapefruit and other citrus fruits, was determined to be an effective anti-inflammatory compound. We investigated the effect of naringin on the key mediators of arthritic inflammation, namely T cell subsets, CD4+GITR+ expressing cells, CD4+CD25+Foxp3+ (Treg), Th1/Th2 cytokines and inflammatory mediators. We treated Balb/c mice (p.o.) with naringin (20, 40 and 80 mg/kg) for 14 days. Compared with the vehicle-treated and arthritic-control mice, the naringin treatment demonstrated a considerable decrease in the level of T cells, CD4+GITR+, Th1 cytokine and inflammatory mediator expressions. In contrast, naringin treatment resulted in significantly up-regulated Treg and Th2 cytokine levels. Therefore, the naringin-induced inhibition of the T cells, various pro-inflammatory cytokines and inflammatory mediators that facilitate cellular infiltration into the joints might have contributed to its anti-arthritic activity. Our data suggest that naringin diminished the AIA in mice and it could be a potential alternative/adjunct treatment for RA.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Immunology - Volume 287, Issue 2, February 2014, Pages 112–120
نویسندگان
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