کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2167234 | 1549413 | 2012 | 9 صفحه PDF | دانلود رایگان |
House dust mite (HDM), the most common allergen, activate both the IgE-associated and innate immune responses. To clarify the process of sensitization, we investigated the role of the CCL21, CCL19, and CCR7 axis in a mouse model of HDM-induced allergic asthma. HDM inhalation without systemic immunization resulted in a HDM-specific IgE response. CCR7-knockout (CCR7KO) mice exhibited greater airway inflammation and IgE responses compared to wild-type mice. We examined FoxP3 expression in these mice to clarify the contribution of regulatory cells to the responses. FoxP3 expression was higher in the lungs but not in the lymph nodes of CCR7KO mice compared to wild-type mice. In CCR7KO mice, FoxP3-positive cells were found in lung, but we observed higher release of IL-13, IL-5, TGF-β, IL-17, and HMGB1 in bronchoalveolar lavage fluid. We demonstrate here that immuno-regulation through CCR7 expression in T cells plays a role in HDM-specific sensitization in the airway.
► CCR7KO mice display severe allergic airway inflammation by continuous HDM inhalation.
► The prominent lymphoid aggregates were observed in CCR7KO mice after HDM exposure.
► The number of FoxP3 positive cells in the lung was increased in CCR7KO mice.
► Th2 cytokine as well as IL-17 and TGFβ were increased in CCR7KO mice.
► HMGB1 production was prominent in CCR7KO mice.
Journal: Cellular Immunology - Volume 275, Issues 1–2, January–February 2012, Pages 24–32