کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2167273 | 1092323 | 2011 | 5 صفحه PDF | دانلود رایگان |
Anti-inflammatory actions of the vitamin E fragment tocotrienol have not been described for microglia. Here, we screened palm α-, γ- and δ-tocotrienol isoforms and Tocomin® 50% (contains spectrum of tocotrienols and tocopherols) for their ability to limit nitric oxide (NO) production by BV2 microglia. Microglia were treated with varying doses of tocotrienols for 24 h and stimulated with 1 μg/ml lipopolysaccharide (LPS). All tocotrienol isoforms reduced NO release by LPS-stimulated microglia, with 50 μM being the most potent tocotrienol dose. Of the isoforms tested, δ-tocotrienol lowered NO levels the most, reducing NO by approximately 50% at 48 h post-LPS treatment (p < .05). None of the tocotrienol doses tested affected microglia viability.
► Tocotrienol action on microglia has not been reported.
► Three tocotrienol fragments screened for effects on microglia production of NO.
► All tocotrienol fragments displayed ability to reduce microglial NO.
► δ-tocotrienol was most potent, capable of reducing NO levels by approximately 50%.
Journal: Cellular Immunology - Volume 271, Issue 2, 2011, Pages 205–209