کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2167274 | 1092323 | 2011 | 4 صفحه PDF | دانلود رایگان |
Th1 cells are remarkably more susceptible to activation induced cell death than Th17. Here, we compared cultures of these two cell subpopulations for their expression of apoptosis-related molecules when re-exposed to their specific antigen. We also compared the expression of apoptosis-related molecules in the mouse eye with inflammation induced by Th1 or Th17 cells. Using qPCR we found that the mRNA transcript levels of the majority of tested apoptosis-related molecules were higher in the Th1 cultures, and in eyes with Th1-induced inflammation. Apoptotic intrinsic pathway molecules played minor roles in the processes in vitro or in vivo, whereas extrinsic pathway molecules, as well as PD-1, its ligands and Tim3, were heavily involved.
► Th1 cell cultures express apoptosis-related molecules more than Th17 cells do.
► Th1-induced inflammation highly involves apoptosis-related molecules.
► Extrinsic pathway of apoptosis participates in immune-mediated inflammation.
Journal: Cellular Immunology - Volume 271, Issue 2, 2011, Pages 210–213