Electrochemical determination of ezetimibe by MgO nanoflakes-modified carbon paste electrode

• MgONF modified CPE is used for first time in the determination of ezetimibe.
• Modified electrode exhibits catalytic effect towards the electro-oxidation of Ezetimibe.
• This method is used for the determination of Ezetimibe in pharmaceutical preparations.

In the present work, magnesium oxide nanoflakes (MgONF) were synthesized using cetyl trimethyl ammonium bromide (CTAB) in a co-precipitation method. The prepared MgONF were characterized using X-ray diffraction (XRD) and scanning electron microscopy (SEM). They were used for the preparation of modified carbon-paste electrode and successfully used to study the electrochemical behavior of ezetimibe (Eze) in phosphate buffer solution (PB, pH 7.0) by cyclic voltammetric technique (CV). The results show that MgONF-modified CPE can remarkably enhance the electrocatalytic activity towards the oxidation of Eze. The effect of pH and scan rate was also investigated. A linear relationship was obtained between the anodic peak current and the Eze concentration in the range 2 × 10− 7 to 1.0 × 10− 5 M with a correlation co-efficient of 0.999. The detection limit (LOD) and quantification limit (LOQ) at MgONF-modified CPE were found to be 5 × 10− 8 and 2 × 10− 7 M respectively by differential pulse voltammetric technique (DPV). The proposed method was successfully applied for the determination of Eze in commercial tablet sample.

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