کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2202551 1551376 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Viruses that ride on the coat-tails of actin nucleation
ترجمه فارسی عنوان
ویروس هایی که روی کت دم هستن آکتین سوار می شوند
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
چکیده انگلیسی

Actin nucleation drives a diversity of critical cellular processes and the motility of a select group of viral pathogens. Vaccinia virus and baculovirus, Autographa californica multiple nucleopolyhedrovirus, recruit and activate the cellular actin nucleator, the Arp2/3 complex, at the surface of virus particles thereby instigating highly localized actin nucleation. The extension of these filaments provides a mechanical force that bestows the ability to navigate the intracellular environment and promote their infectious cycles. This review outlines the viral and cellular proteins that initiate and regulate the signalling networks leading to viral modification of the actin cytoskeleton and summarizes recent insights into the role of actin-based virus transport.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cell & Developmental Biology - Volume 46, October 2015, Pages 155–163
نویسندگان
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