Sulfanilamide and silver nanoparticles-loaded polyvinyl alcohol-chitosan composite electrospun nanofibers: Synthesis and evaluation on synergism in wound healing

• The novel AgNP's and sulfanilamide loaded PVA/CS composite nanofibers are fabricated by electrospinning.
• The composite nanofibers have pronounced drug release capabilities.
• The composite nanofibers exhibit a synergistic wound healing activity.
• The synthesized AgNP's decorated sulfanilamide loaded nanofibers have an excellent antimicrobial activity toward pathogenic microbes.

Novel silver nanoparticles-decorated chitosan (CS)-polyvinyl alcohol (PVA) composite electrospun nanofibers, loaded with sulfanilamide for enhanced wound healing have been developed. Herein, formic acid was used as a reducing agent to produce in situ colloidal silver nanoparticles (AgNPs) in the composite polymeric solution with the active agent sulfanilamide. The prepared electrospun fibers were characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction, ultraviolet spectroscopy, and thermal gravimetric analysis (TG). Further, in vitro release, antimicrobial properties and in vivo wound healing activity were evaluated. The results revealed that the composite fibers displayed a synergistic antibacterial and wound healing activities.

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