کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
235641 465643 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dextran and its potential use as tablet excipient
ترجمه فارسی عنوان
دکتران و پتانسیل استفاده از آن به عنوان قرص امکان پذیر است
کلمات کلیدی
دکستران، ترامادول، جدول پذیری، ورم، انتشار مواد مخدر
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
چکیده انگلیسی


• Dextrans show excellent tabletability.
• The moisture markedly affects the dextran properties only for samples at low MW.
• Drug dissolution is strictly dependent on the dextran Mw.
• The matrices show swelling or erosion behaviour as a function of dextran Mw.

Dextrans are a class of carbohydrate polymers extensively applied in pharmaceutical applications, particularly as drug conjugate macromolecular carriers or drug delivery systems. These polysaccharides improve the stability of the therapeutics enabling also the control of their release, via either the parenteral and or oral routes. In the latter case, due to their gel forming ability they may have potential as hydrophilic matrix tablets for sustained drug release.In this paper, we investigated the behaviour of different molecular weight (1, 40, 500 and 2300 kDa) dextrans as tabletting excipients. Powder particle size and hygroscopic studies have been reported, together with tabletability, tablet stability and tablet swelling. Moreover we use tramadol as model compound to evaluate the ability of dextrans to control drug dissolution. The results suggest that dextrans with lower molecular weights may be a promising excipient to be used as filler for immediate release tablets, due to their good tabletability and fast dissolution rate, while dextrans with higher molecular weights could be an efficient disintegrant due to their swelling ability.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Powder Technology - Volume 273, March 2015, Pages 125–132
نویسندگان
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