کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2426431 1553153 2016 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The pharmacology of effort-related choice behavior: Dopamine, depression, and individual differences
ترجمه فارسی عنوان
فارماکولوژی رفتار انتخابی مربوط به تلاش: دوپامین، افسردگی و تفاوتهای فردی
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
چکیده انگلیسی


• Antagonism of dopaminereceptors or dopamine depletion alters effort-related choice behavior.
• Dopamine interacts with other neurotransmitters to regulateeffort-based choice.
• Conditions associated with depression in humans altereffort-related choice in rodents.
• Tests of effort-based choice are being used as animal models ofaspects of psychopathology.
• There is an important dopaminergic component to effort-relatedmotivational effects.

This review paper is focused upon the involvement of mesolimbic dopamine (DA) and related brain systems in effort-based processes. Interference with DA transmission affects instrumental behavior in a manner that interacts with the response requirements of the task, such that rats with impaired DA transmission show a heightened sensitivity to ratio requirements. Impaired DA transmission also affects effort-related choice behavior, which is assessed by tasks that offer a choice between a preferred reinforcer that has a high work requirement vs. less preferred reinforcer that can be obtained with minimal effort. Rats and mice with impaired DA transmission reallocate instrumental behavior away from food-reinforced tasks with high response costs, and show increased selection of low reinforcement/low cost options. Tests of effort-related choice have been developed into models of pathological symptoms of motivation that are seen in disorders such as depression and schizophrenia. These models are being employed to explore the effects of conditions associated with various psychopathologies, and to assess drugs for their potential utility as treatments for effort-related symptoms. Studies of the pharmacology of effort-based choice may contribute to the development of treatments for symptoms such as psychomotor slowing, fatigue or anergia, which are seen in depression and other disorders.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Processes - Volume 127, June 2016, Pages 3–17
نویسندگان
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