کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2446813 1553848 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Failure to induce alopecia areata in C3H/HeJ mice with exogenous interferon gamma
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Failure to induce alopecia areata in C3H/HeJ mice with exogenous interferon gamma
چکیده انگلیسی

Alopecia areata is a cell mediated autoimmune disease that targets actively growing, anagen stage hair follicles in several mammalian species. Upregulation of MHC I due to interferon gamma is considered to be one of the initiating steps. To test this hypothesis we used the spontaneous C3H/HeJ mouse model, induced anagen by wax stripping the skin, and injected recombinant murine interferon gamma. Alopecia areata is a complex polygenic trait with low penetrance in these mice. Injection of interferon gamma did not change the frequency or time of onset of alopecia in these mice suggesting this protein alone is not sufficient to initiate disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Experimental Animal Science - Volume 43, Issue 4, 26 February 2007, Pages 265–270
نویسندگان
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