کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
2522634 1119361 2019 7 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله
[2-14C]Ethanol as a precursor of glutamine, glutamate, γ-aminobutyric acid and aspartate in hamster brain in vivo
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
[2-14C]Ethanol as a precursor of glutamine, glutamate, γ-aminobutyric acid and aspartate in hamster brain in vivo
چکیده انگلیسی
When [2-14C]ethanol is injected intraperitoneally into hamsters, radioactive carbon is incorporated in the brain into glutamate and glutamine at a rate equivalent to 0.02 μmole ethanol/g/min and into aspartate and γ-aminobutyric acid (GABA) at a rate of 0.003 μmole/g/min. This incorporation is linear for at least 90 min after ethanol administration. Acetate formed from the hepatic oxidation of [2-14C]-ethanol seems to be the principal source of radioactive carbon entering the amino acids. Significantly more ethanol-derived acetate is incorporated into glutamine and GABA after a high ethanol dose (2.50 g/kg) than after a low dose (0.62 g/kg).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical Pharmacology - Volume 21, Issue 15, 1 August 1972, Pages 2013-2019
نویسندگان
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