کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2526056 1558006 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel 9, 10-dihydrophenanthrene derivatives from Eria bambusifolia with cytotoxicity aganist human cancer cells in vitro
ترجمه فارسی عنوان
9، 10-dihydrophenanthrene جدید بدست آمده از bambusifolia Eria با اثرات سیتوتوکسیک علیه سلول‌های سرطانی انسان در شرایط آزمایشگاهی
کلمات کلیدی
bambusifolia Eria؛ 9، 10، Dihydrophenanthrene؛ Erathrins A و B؛ اثرات سیتوتوکسیک
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی طب مکمل و جایگزین
چکیده انگلیسی

The present study was designed to identify bioactive compounds similar to those isolated from Dendrobium genus from its relative specie Eria bambusifolia. Compounds 1–10 were isolated and purified using silica gel, MCI CHP-20 gel, Sephadex LH-20, and Lichroprep RP-18 chromatography methods. Their structures were elucidated by means of extensive spectroscopic analyses. The cytotoxicity of these compounds against five human cancer cell lines was tested. Erathrins A and B (1 and 2) were new compounds, and compound 1 represented a novel carbon framework having a phenanthrene-phenylpropane unit with a dioxane moiety. Moreover, compound 1 showed selective cytotoxic activity against HL-60 cells (IC50 = 14.50 μmol·L−1). These results provided a basis for future development of these agents as anticancer lead compounds.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Journal of Natural Medicines - Volume 14, Issue 8, August 2016, Pages 621–625
نویسندگان
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