کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2538058 1559632 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Flavonoids stimulate cholecystokinin peptide secretion from the enteroendocrine STC-1 cells
ترجمه فارسی عنوان
فلاونوئیدها باعث تحریک ترشح پپتید کوله سیستوکینین از سلول های enteroendocrine STC-1 می شود
کلمات کلیدی
CCK، کوله سیستوکینین؛ RIA، radioimmunoassayCholecystokinin؛ سلول های STC-1 ؛ فلاونوئیدها؛ مصرف غذا
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
چکیده انگلیسی

Animal experiments showed that flavonoids might have the potential for an anti-obesity effect by reducing weight and food intake. However, the exact mechanisms that could be involved in these proposed effects are still under investigation. The complex process of food intake is partially regulated by gastrointestinal hormones. Cholecystokinin (CCK) is the best known gastrointestinal hormone to induce satiety signal that plays a key role in food intake regulation. It is released from the endocrine cells (I cell) in response to the ingestion of nutrients into the small intestine. In this study, we investigated the possible effects of flavonoids (quercetin, kaempferol, apigenin, rutin and baicalein) on stimulation of CCK release in vitro using enteroendocrine STC-1 cells. In comparison with the control, quercetin, kaempferol and apigenin resulted in a significant increase in CCK secretion with quercetin showing the highest activity. On the other hand, no significant effect was seen by rutin and baicalein.To our knowledge, this is the first report to study the stimulation of CCK peptide hormone secretion from STC-1 cells by quercetin and kaempferol, rutin, apigenin and baicalein. Based on the cell-based results in this work, it can be suggested that the reported activity of flavonoids against food intake and weight could be mediated by stimulation of CCK signal which in turn is responsible for food intake reduction, but future animal and human studies are needed to confirm this conclusion at organism level.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 113, September 2016, Pages 128–131
نویسندگان
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