کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2547377 | 1124056 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Protective effect of Lygodium flexuosum (L.) Sw. extract against carbon tetrachloride-induced acute liver injury in rats
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کلمات کلیدی
DTNBMDACPCSEACCl4ALTTBARSKClGSHTBAAST - آسپارتات ترانس آمینازAspartate aminotransferase - آسپارتات ترانس آمیناز یا AST Alanine aminotransferase - آلانین آمینوترانسفرازThiobarbituric acid - اسید تیوباربیتوریکHepatotoxicity - سمیت کبدPhytochemicals - فیتوکمیکال هاlactate dehydrogenase - لاکتات دهیدروژناز LDH - لاکتات دهیدروژناز به صورت مختصر شده LDH malondialdehyde - مالون دی آلدهیدthiobarbituric acid reactive substance - واکنش پذیر اسید تیوباربیتوریکreduced glutathione - کاهش گلوتاتیونCarbon tetrachloride - کربن تتراکلریدPotassium chloride - کلرید پتاسیمCommittee for the Purpose of Control and Supervision of Experiments on Animals - کمیته هدف کنترل و نظارت بر آزمایشات روی حیوانات
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The hepatoprotective potential of Lygodium flexuosum (L.) Sw. was evaluated in male Wistar rats against carbon tetrachloride-induced liver damage in preventive and curative models. Toxic control and n-hexane extract-treated rats received a single dose of CCl4 (150 μL/100 g, 1:1 in corn oil). Pre-treated rats were given n-hexane extracts at 200 and 100 mg/kg dose 48, 24 and 2 h prior to CCl4 administration. In post-treatment groups, rats were treated with n-hexane extract at a dose of 200 and 100 mg/kg, 2, 24 and 48 h after CCl4 intoxication. Rats pre-treated with Lygodium flexuosum remarkably prevented the elevation of serum AST, ALT, LDH and liver lipid peroxides in CCl4-treated rats. Rats treated with the extract after the establishment of CCl4 induced liver injury showed significant (p â¤Â 0.05) protection of liver as evidenced from normal AST, ALT, LDH and MDA levels. Hepatic glutathione levels were significantly (p â¤Â 0.05) increased by the treatment with the extracts in both the experimental groups. Histopathological changes induced by CCl4 were also significantly (p â¤Â 0.05) reduced by the extract treatment in preventive and curative groups. Phytochemical studies revealed the presence of saponins, triterpenes, sterols and bitter principles in Lygodium flexuosum n-hexane extract which could be responsible for the possible hepatoprotective action.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 108, Issue 3, 6 December 2006, Pages 320-326
Journal: Journal of Ethnopharmacology - Volume 108, Issue 3, 6 December 2006, Pages 320-326
نویسندگان
P.J. Wills, V.V. Asha,