کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2548738 1124468 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mechanisms of pentazocine-induced ventilatory depression and antinociception in anesthetized rats
ترجمه فارسی عنوان
مکانیسم افسردگی تنفسی ناشی از پنتازوسین و اثرات ضددردی در موشهای صحرایی بیهوش
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
چکیده انگلیسی

This study was performed to clarify mechanisms underlying pentazocine-induced ventilatory depression and antinociception. Spontaneous ventilation and hind leg withdrawal response against nociceptive thermal stimulation were simultaneously recorded in anesthetized rats. Pentazocine decreased minute volume resulting from depression of the ventilatory rate and tracheal airflow, and prolonged the latency of withdrawal response. Pre-treatment of β-funaltorexamine, but not nor-binaltorphimine, significantly attenuated pentazocine-induced ventilatory depression, while either antagonist weakened its analgesic potency. Comparing with effects of fentanyl and U50488, the present results suggest that ventilatory depression induced by pentazocine is mediated by mainly μ receptors and analgesia by both μ and κ receptors.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmacological Sciences - Volume 130, Issue 3, March 2016, Pages 181–184
نویسندگان
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