کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2576393 1561353 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Characterization of the kynurenine pathway in human oligodendrocytes
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
Characterization of the kynurenine pathway in human oligodendrocytes
چکیده انگلیسی

It is important to understand the involvement of oligodendrocytes in the kynurenine pathway (KP) and more particularly, their potential ability to produce neuroprotective metabolites such as kynurenic acid (KYNA) or picolinic acid (PIC), and the possibility of taking up and catabolizing the excitotoxin quinolinic acid (QUIN). These mechanisms may play a crucial role in the pathophysiology of neuroinflammatory diseases, especially multiple sclerosis. We used RT-PCR and HPLC to delineate KP enzyme expression and KP metabolite production. We characterized the KP in oligodendrocytes and showed that they lack IDO expression and are unable to catabolize tryptophan. However, the other enzymes in the pathway are present. These results indicate that human oligodendrocytes are more likely to produce neuroprotective KP metabolites such as KYNA and PIC rather than QUIN. However, because of the lack of IDO they are not able to down-regulate the immune response and as such may be more vulnerable to autoimmune phenomena.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Congress Series - Volume 1304, 1 November 2007, Pages 213–217
نویسندگان
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