Antihepatotoxic efficacy of Mangifera indica L. polysaccharides against cyclophosphamide in rats

• I follow up the reviewer's comments step by step.
• The Yield and chemical composition of the extracted polysaccharides made according to the reviewers comments.
• The histopathological photos improved from the resolution point and comments according to the reviewers comments.
• The discussion revised to relate the chemical composition of the extracted polysaccharides to our findings.

The present study aims to evaluate the possible protective role of polysaccharides extracted from the Egyptian mango Mangifera indica L. (MPS) and/or silymarine against cyclophosphamide (CP) toxicity in male albino rats. The MPS and/or silymarin significantly decreased the activities of serum ASAT and ALAT. However, MPS (1000 mg/kg) normalized their activities towards the normal levels recording 28.75 and 78.75 U/ml respectively. The recorded data also showed the antioxidant effect of MPS by decreasing the level of malondialdehyde (MDA) and increasing the level of reduced glutathione (GSH) as well as normalized the activities of the antioxidant enzyme GST and SOD. Histopathological examinations also confirmed the protective efficacy of MPS against liver toxicity of CP. In conclusion, the recorded results of the present study support the protective role of MPS and/or silymarin against CP-induced hepatic damage.