کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2628945 | 1136505 | 2015 | 10 صفحه PDF | دانلود رایگان |
• A double-blind-randomized-controlled trial.
• Low dose combination of Turmeric and Black seeds are effective in metabolic syndrome.
• Turmeric and Black seeds with lifestyle modification can be recommended in MetS.
SummaryObjectiveTo compare the clinical efficacy of Black seeds and Turmeric alone and its co-administration in lower doses among patients with metabolic syndrome (MetS).DesignDouble-blind-randomized-controlled trial.SettingHijrat colony, Karachi, Pakistan.InterventionApparently healthy males (n = 250), who screened positive for MetS, were randomized to either Black seeds (1.5 g/day), Turmeric (2.4 g/day), its combination (900 mg Black seeds and 1.5 g Turmeric/day) or placebo for 8 weeks. Main outcome measures: body-mass-index (BMI), body-fat-percent (BF%), waist-circumference (WC), hip-circumference (HC), blood pressure (BP), lipid-profile (cholesterol, HDL-cholesterol, LDL-cholesterol and TG), fasting blood glucose (FBG) and c-reactive protein (CRP).ResultsAt 4 weeks, compared to baseline, Black seed and Turmeric alone showed improvement in BMI, WC and BF%. Combination improved all parameters except HDL-cholesterol with lower FBG and LDL-cholesterol as compared to placebo. At 8 weeks, compared to placebo, Black seeds reduced lipids and FBG, while Turmeric reduced LDL-cholesterol and CRP. Interestingly, combination group with 60% dose of the individual herbs showed an improvement in all parameters from baseline. When compared to placebo, it reduced BF%, FBG, cholesterol, TG, LDL-cholesterol, CRP and raised HDL-cholesterol.ConclusionTurmeric and Black seeds showed improvement in all parameters of metabolic syndrome, when co-administered at 60% of doses of individual herbs with enhanced efficacy and negligible adverse-effects. The combination of Black seeds and Turmeric can therefore, be recommended with lifestyle modification as a starting point for patients with MetS to halt its future complications and progression.
Journal: Complementary Therapies in Medicine - Volume 23, Issue 2, April 2015, Pages 165–174