کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
2650303 1139367 2016 5 صفحه PDF ندارد دانلود رایگان
عنوان انگلیسی مقاله
Aminocaproic acid for the management of bleeding in patients on extracorporeal membrane oxygenation: Four adult case reports and a review of the literature
ترجمه فارسی عنوان
اسید آمینو کاپرویک برای مدیریت خونریزی بیماران تحت اکسیژن غشای خارج از بدن: چهار مورد گزارش به بزرگسالان و بررسی مقالات
کلمات کلیدی
اکسیژن غشای خارج؛ اسید آمینو کاپرویک؛ خونریزی؛ هموستاز
Extracorporeal membrane oxygenation; Antifibrinolytic agents; Aminocaproic acid; Hemorrhage; Hemostasis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی


• In patients with refractory bleeding, EACA provided clot stabilization.
• Antifibrinolytics may have unique efficacy in ECMO compared to other agents.
• EACA may be safer than that of coagulation factor repletion.

BackgroundExtracorporeal membrane oxygenation (ECMO) is associated with a significant risk of bleeding and thrombosis. Despite high rates of bleeding and bleeding-related mortality in patients on ECMO, there is little evidence available to guide clinicians in the management of ECMO-associated bleeding.MethodsWe report the use of aminocaproic acid in four patients with bleeding on ECMO and a review of the literature.ResultsHigh D-dimer levels and low fibrinogen levels suggested that an antifibrinolytic agent may be effective as an adjunct to control bleeding. After aminocaproic acid administration, bleeding was controlled in each patient as evidenced by clinical and laboratory parameters. One patient suffered a cardiac arrest and care was withdrawn.ConclusionsIn patients on ECMO with evidence of fibrinolysis, aminocaproic acid may be an effective option to control bleeding and to stabilize clot formation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Heart & Lung: The Journal of Acute and Critical Care - Volume 45, Issue 3, May–June 2016, Pages 232–236
نویسندگان
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