کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
2650387 1139380 2015 4 صفحه PDF ندارد دانلود رایگان
عنوان انگلیسی مقاله
Potential biomarkers for early diagnosis of acute aortic dissection
ترجمه فارسی عنوان
بیومارکرهای بالقوه برای تشخیص زودهنگام تشریح آئورت حاد
کلمات کلیدی
تشخیص حاد آئورت؛ بیومارکرها؛ اکتین عضلانی آلفا صاف؛ زنجیره سنگین میوزین عضله صاف ؛ قطعات الستین قابل حل؛ Polycystin 1؛ D- دایمر
Acute aortic dissection; Biomarkers; α-Smooth muscle actin; Smooth muscle myosin heavy chain; Soluble elastin fragments; Polycystin 1; D-dimer
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

ObjectiveThe purpose of this study was to identify biological markers for early diagnosis of acute aortic dissection (AAD).Methods76 patients presented to the emergency room with acute chest pain within 6 h of occurrence were recruited for this study, and AAD diagnosed by aortic CTA. Biomarkers were measured by ELISA. ROC curve and Pearson correlation analysis were used to evaluate the sensitivity and specificity to diagnosis of AAD.ResultsThe serum levels of α-SMA, smMHC, sELAF, PC1 and D-dimer were significantly higher in AAD patients than in other groups (P < 0.05). Significant correlations between smMHC, sELAF, PC1, and D-dimer level were observed in AAD. Any combination of two markers showed good sensitivity (94.29%) and specificity (85.37%).ConclusionsmMHC, sELAF, PC1, or D-dimer alone is a biomarker for early diagnosis of AAD, but the combination of these markers has significantly higher diagnostic value.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Heart & Lung: The Journal of Acute and Critical Care - Volume 44, Issue 3, May–June 2015, Pages 205–208
نویسندگان
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