کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2686597 1142966 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Phenolics extract of Tetrapleura tetraptera fruit inhibits xanthine oxidase and Fe2+-induced lipid peroxidation in the kidney, liver, and lungs tissues of rats in vitro
ترجمه فارسی عنوان
عصاره فنولیک میوه تتراپلورا تتراپترا باعث جلوگیری از پراکسیداسیون لیپید شده توسط Fe2 + و زانتین اکسیداز در بافت های کلیه، کبد و ریه در موش های آزمایشگاهی
کلمات کلیدی
چهار ضلعی تتراپترا؛ فنولیک؛ گزانتین اکسیداز؛ هیپریریسمی؛ پراکسیداسیون لیپید
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
چکیده انگلیسی

The phenolics composition and inhibitory activity of Tetrapleura tetraptera fruit extract on xanthine oxidase (XO) and Fe2+-induced lipid peroxidation in the kidney, liver and lungs tissues of rats were evaluated in vitro. Phenolics (flavonoids and phenolic acids) were quantified using reverse-phase high performance liquid chromatrography coupled with diode array detection (HPLC-DAD). The XO and Fe2+-induced lipid peroxidation inhibitory abilities of the extract were evaluated using spectrophotometric methods. The extract contained some flavonoids and phenolic acids, including catechin, epicatechin, rutin, quercetin, luteolin, apigenin; gallic, chlorogenic, caffeic and ellagic acids that are beneficial to health. The extract inhibited XO in the kidney, liver and lungs tissues in a dose-dependent manner. The half-maximal inhibitory concentrations (IC50) of the extract on XO from the tissues varied significantly (P < 0.05), and were in the order of liver > kidney > lungs. The extract also inhibited Fe2+-induced lipid peroxidation in a dose-dependent pattern, having IC50 in the order of liver > lungs > kidney. T. tetraptera fruit extract could be a promising nutraceutical for preventing and managing hyperuricaemia and the associated disease conditions, due to its ability to inhibit XO; this bioactivity is attributable to combined effect of its flavonoids and phenolic acids.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food Science and Human Wellness - Volume 5, Issue 1, March 2016, Pages 17–23
نویسندگان
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