Peripheral nerve block in patients with Ehlers-Danlos syndrome, hypermobility type: a case series

• There were no block complications for patients with Ehlers–Danlos Syndrome hypermobility subtype.
• The block failure rate was higher than expected based on previously published data.
• Other subtypes of Ehlers-Danlos require further investigation.

Study ObjectiveEhlers-Danlos syndrome (EDS) is an inherited disease characterized by defects in various collagens or their post translational modification, with an incidence estimated at 1 in 5000. Performance of peripheral nerve block in patients with EDS is controversial, due to easy bruising and hematoma formation after injections as well as reports of reduced block efficacy. The objective of this study was to review the charts of EDS patients who had received peripheral nerve block for any evidence of complications or reduced efficacy.DesignCase series, chart review.SettingAcademic medical center.PatientsPatients with a confirmed or probable diagnosis of EDS who had received a peripheral nerve block in the last 3 years were identified by searching our institutions electronic medical record system.InterventionsThe patients were classified by their subtype of EDS. Patients with no diagnosed subtype were given a probable subtype based on a chart review of the patient's symptoms.MeasurementsPatient charts were reviewed for any evidence of complications or reduced block efficacy.Main ResultsA total of 21 regional anesthetics, on 16 unique patients were identified, 10 of which had a EDS subtype diagnosis. The majority of these patients had a diagnosis of hypermobility-type EDS. No block complications were noted in any patients. Two block failures requiring repeat block were noted, and four patients reported uncontrolled pain on postoperative day one despite successful placement of a peripheral nerve catheter. Additionally, blocks were performed without incident in patients with classical-type and vascular-type EDS although the number was so small that no conclusions can be drawn about relative safety of regional anesthesia in these groups.ConclusionsThis series fails to show an increased risk of complications of peripheral nerve blockade in patients with hypermobility-type EDS.