کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2773097 1567897 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Low magnesium is not a significant predictor of hard events in acute myocardial infarction
ترجمه فارسی عنوان
منیزیم کم یک پیش بینی کننده قابل توجه از رویداد های سخت در انفارکتوس حاد قلبی نیست
کلمات کلیدی
منیزیم؛ انفارکتوس حاد میوکارد؛ پیش آگهی؛ رویداد سخت
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی بالینی
چکیده انگلیسی


• It has been hypothesized that Mg may play a key role in ischemic heart disease.
• Mg role as predictor for HE-death, nonfatal myocardial infarction-in AMI was studied.
• Our results do not give support for a role of hypomagnesia as HE predictor in AMI.

BackgroundAlthough magnesium (Mg) has recognized cardioprotective properties and hypomagnesemia is common in patients with acute myocardial infarction (AMI), data regarding the role of Mg as prognostic factor for adverse events are scarce, as well as there are conflicting results on the use of Mg as adjuvant therapy in AMI.AimTo evaluate the role of Mg as predictor for hard events (HE, all cause death, and nonfatal myocardial infarction) in AMI patients.Design and patientsWe studied 406 AMI patients (306 males, age: 67 ± 12 years, mean ± SD). Patient data were collected from the Institute electronic databank which saves demographic, clinical, instrumental, therapeutical and follow-up data of all patients admitted to our Coronary Unit.ResultsDuring a mean follow-up period of 21 ± 18 months, the combined endpoint accounted for 63 HE, 44 (11%) deaths (35 cardiac deaths), 19 (5%) nonfatal MI.The multiple regression model identified glycemia as the only independent determinant of Mg in AMI pts. (T value = − 2.8, standard coefficient = − 0.15, p < 0.01). The Kaplan–Meier survival estimates failed to show a significantly worst outcome in patients presenting low Mg (< 0.783 mmol/L, 25th percentile). Aging (> 67 years—50th percentile), and ejection fraction (< 40%) remained as prognostic factors for HE in the adjusted Cox multivariate proportional hazard model (HR = 2.8, 95% CI = 1.6–5, p < 0.001; HR = 3.2, 95% CI = 1.9–5.3 p < 0.001, respectively).ConclusionThe present findings do not support a significant role of low Mg as predictor for HE in AMI.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: BBA Clinical - Volume 5, June 2016, Pages 130–133
نویسندگان
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