کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
2774983 1152303 2016 3 صفحه PDF ندارد دانلود رایگان
عنوان انگلیسی مقاله
Plasmablastic lymphoma presenting as a large intracardiac mass and bilateral pleural effusions
ترجمه فارسی عنوان
ارائه لنفوم Plasmablastic به عنوان توده intracardiac بزرگ و پلورال افیوژن دوطرفه
کلمات کلیدی
لنفوم Plasmablastic؛ ویروس Epstein-Barr؛ لنفوم قلبی؛ HHV8
Plasmablastic lymphoma; Epstein–Barr virus; Primary cardiac lymphoma; HHV8
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی بالینی
چکیده انگلیسی

Plasmablastic lymphoma (PBL) is a rare aggressive lymphoma arising most frequently in the oral cavity of HIV-infected patients. Rare cases of PBL have been reported in extra-oral sites, as well as in HIV-negative patients. Cardiac involvement by lymphoma is very rare. The most common primary cardiac lymphoma is diffuse large B-cell lymphoma. We report an unusual case of PBL in a 49-year-old, HIV-positive man presenting with a large intracardiac mass and bilateral pleural effusions. Histological examination of the cardiac mass biopsy and cytological evaluation of the pleural fluid demonstrated large lymphoma cells with plasmablastic differentiation. By immunohistochemistry, the large lymphoma cells expressed CD30, CD45, CD138, MUM1, and kappa light chain, were weakly positive for EMA, and were negative for T-cell and B-cell markers, lambda light chain, and human herpes virus 8 (HHV8). In situ hybridization for Epstein Barr Virus-encoded RNA (EBER) was negative in large lymphoma cells. To our knowledge, in the English literature, this is the second reported case of PBL with cardiac origin and the first reported case of PBL that presents as a combination of intracardiac mass and pleural effusions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental and Molecular Pathology - Volume 100, Issue 1, February 2016, Pages 79–81
نویسندگان
, , , , ,