Plasminogen deficiency is associated with improved glucose tolerance, and lower DPP-4 activity

• Plg deficiency is associated with improved glucose tolerance.
• Plg deficiency is associated with enhanced insulin secretion.
• Plg deficiency is associated with lower DPP-4 activity in mice.

Plasminogen (Plg), which is the inactive form of plasmin, deficiency enhanced insulin secretion, and was associated with improved oral glucose tolerance in mice. Additionally, Plg deficiency was associated with lower dipeptidyl peptidase-4 (DPP-4) activity, and enhanced glucagons-like peptide-1 (GLP-1) expression. Plg may regulate the DPP-4 activity and the glucose metabolism.