کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2796511 1155605 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Use of antidepressants and statins and short-term risk of new-onset diabetes among high risk adults
ترجمه فارسی عنوان
استفاده از داروهای ضد افسردگی و استاتین و خطر کوتاه مدت ابتلا به دیابت در میان افراد مبتلا به بالا بودن خطر
کلمات کلیدی
داروهای ضد افسردگی، استاتین ها، ابتلا به دیابت
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی

AimsWe evaluated the association of combined use of antidepressants and statins and the risk of new-onset diabetes among high-risk adults.MethodsWe used a retrospective, observational, longitudinal design among adults (age ≥22 years) who were diabetes free at baseline and had reported hypertension or hyperlipidemia or heart disease. We used data were from 2004 to 2009 Medical Expenditure Panel Survey and identified from self-reported diabetes or insulin use. We categorized antidepressants and statins use into four groups: antidepressants only, statins only, combined use of antidepressants and statins (antidepressants–statins), and neither antidepressant nor statins. We conducted chi-square and multivariable logistic regressions to examine the association between use of antidepressants–statins and new-onset diabetes after controlling for demographic and economic characteristics, health-status, access to care, presence of depression, and lifestyle risk factors.ResultsIn our study sample, 9.3% used antidepressants only, 10.7% used statins only and 2.4% adults reported use of antidepressants–statins. Nearly 2% of the study sample reported new-onset diabetes. In unadjusted analyses, significantly higher proportion of adults using antidepressants–statins (3.2%) reported new-onset diabetes compared to those using neither antidepressants nor statins (1.1%). However, after controlling for all other variables in multivariable regression we did not observe a statistically significant association between use of antidepressants–statins and new-onset diabetes.ConclusionsOur study results do not suggest that use of antidepressants–statins may increase the risk of new-onset diabetes. Future research needs to examine this relationship with specific combinations of these drug classes and using longer follow up periods.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diabetes Research and Clinical Practice - Volume 105, Issue 2, August 2014, Pages 251–260
نویسندگان
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