کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2797662 | 1155661 | 2010 | 4 صفحه PDF | دانلود رایگان |
AimsThe interaction of advanced glycation end products (AGEs) and the receptor for advanced glycation end products (RAGE) has played an important role in the pathogenesis of diabetic nephropathy. In the present study, we measured the relationship of plasma soluble isoform of RAGE (sRAGE) and urinary microalbumin excretion in the early stage of type 2 diabetic nephropathy.Methods180 patients with early stage of type 2 diabetic nephropathy were recruited into the study. Plasma sRAGE and the characterized AGE carboxymethyllysine (CML) were measured by enzyme-linked immunosorbent assay.ResultsPlasma sRAGE positively correlated with the level of CML (R = 0.22, P = 0.03) while sRAGE was not significantly correlated with the urinary mAlb/Cr (R = 0.15, P = NS). On stepwise linear regression analysis, AGE and GFR were the main independent determinants of plasma sRAGE concentration.ConclusionPlasma sRAGE is not significantly associated with urinary microalbumin excretion in the early stage of diabetic nephropathy while it is correlated positively with circulating AGE and negatively with glomerular filtration rate (GFR).
Journal: Diabetes Research and Clinical Practice - Volume 87, Issue 2, February 2010, Pages 157–160