Enhanced expressions of sodium–glucose cotransporters in the kidneys of diabetic Zucker rats

Diabetes-mediated changes in mRNA expressions of kidney glucose transporters SGLT1 and SGLT2 were investigated in Zucker rats. SGLTs expressions in pre-diabetic obese rats were similar to leans. SGLT1 and SGLT2 levels in diabetic obese rats were 1.6 (P < 0.03) and 4.8 (P < 0.002) folds higher than age-matched leans, respectively.