کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2798184 | 1155681 | 2008 | 8 صفحه PDF | دانلود رایگان |
To investigate the impact of insulin plus other risk factors on cardiovascular disease (CVD) events in patients with type 2 diabetes (T2D), we conducted a retrospective study among patients with T2D from a U.S. managed care plan (n = 342,692). Date of first CVD event was defined as index date. For patients without events, index date was date of last-observed claim. CVD event rates were calculated; odds of CVD event were compared for patients with/without insulin use. Events analyzed included stroke, MI, other cardiac/cerebrovascular events.Among insulin group (n = 14,167), 19 patients/1000 patient-years experienced a CVD event, compared with 22/1000 patient-years in non-insulin group (n = 328,077). Adjusting for risk factors and comorbidities, odds of event for insulin group compared to non-insulin group was 0.66, ranging from 25% lower for patients aged 65+ to 42% lower for patients aged 31–45.Insulin treatment of T2D was associated with reduced risk of CVD events compared to other or no therapy.
Journal: Diabetes Research and Clinical Practice - Volume 81, Issue 1, July 2008, Pages 97–104