Social regulation of adult neurogenesis: A comparative approach

• Adult neurogenesis is regulated by the social environment in a species dependent manner.
• Context mediates how social manipulations up- or down-regulate neurogenesis.
• Adult generated neurons in various brain regions contribute to social processing.

The social environment sculpts the mammalian brain throughout life. Adult neurogenesis, the birth of new neurons in the mature brain, can be up- or down-regulated by various social manipulations. These include social isolation, social conflict, social status, socio-sexual interactions, and parent/offspring interactions. However, socially-mediated changes in neuron production are often species-, sex-, and/or region-specific. In order to reconcile the variability of social effects on neurogenesis, we need to consider species-specific social adaptations and other contextual variables (e.g. age, social status, reproductive status, etc.) that shift the valence of social stimuli. Using a comparative approach to understand how adult-generated neurons in turn influence social behaviors will shed light on how adult neurogenesis contributes to survival and reproduction in diverse species.