کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2802545 1156688 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reviewing the safety of GH replacement therapy in adults
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Reviewing the safety of GH replacement therapy in adults
چکیده انگلیسی

ContextSystematic data on safety of growth hormone (GH) replacement therapy in adult GH deficiency is lacking.ObjectiveTo systematically describe safety of adult GH replacement therapy on glucose metabolism and long term safety.DesignA systematic web-based search of PubMed was performed guided by the Standard Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).OutcomeRandomised controlled trials of ≥ 3 months and open trials for ≥ 12 months with more than 50 adult patients (50 patient years, prospective and retrospective) including adverse event reporting as well as articles on mortality primarily on adult onset patients, reporting mortality ratios on GH treated patients, were included for the review.ResultsBased on the defined selection criteria 94 studies were included. The short-term early placebo controlled trials did not demonstrate an increased frequency of diabetes mellitus (DM) and the long-term open studies did not consistently show an increased incidence of DM during GH replacement. The concern that long-term GH replacement might increase the risk of primary cancer, secondary neoplasia after tumour treatment and recurrence of previous tumours was not evident in the study data.ConclusionBased on available data, short- and long-term adult GH replacement in patients with severe GH deficiency and hypopituitarism is safe. However, the small number of subjects, limitation of long-term of GH treatment data and absence of an adequate control population is still a limitation for the interpretation of these data.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Growth Hormone & IGF Research - Volume 25, Issue 4, August 2015, Pages 149–157
نویسندگان
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