کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2808057 1157727 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Expression profile of hypothalamic neuropeptides in chicken lines selected for high or low residual feed intake
ترجمه فارسی عنوان
مشخصات بیان نروپپتید های هیپوتالاموس در خطوط مرغ انتخاب شده برای مصرف خوراکی باقیمانده بالا یا پایین
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی

The R+ and R− chicken lines have been divergently selected for high (R+) or low (R−) residual feed intake. For the same body weight and egg production, the R+ chickens consume 40% more food than their counterparts R− lines. In the present study we sought to determine the hypothalamic expression profile of feeding-related neuropeptides in these lines maintained under fed or food-deprived conditions.In the fed condition, the suppressor of cytokine signaling 3 (SOCS3) was 17-fold lower (P < 0.05) and the ghrelin receptor was 7-fold higher (P < 0.05) in R+ compared to R− chicken lines. The hypothalamic expression of the other studied genes remained unchanged between the two lines. In the fasted state, orexigenic neuropeptide Y and agouti-related peptide were more responsive, with higher significant levels in the R+ compared to R− chickens, while no significant differences were seen for the anorexigenic neuropeptides pro-opiomelanocortin and corticotropin releasing hormone. Interestingly, C-reactive protein, adiponectin receptor 1 and ghrelin receptor gene expression were significantly higher (12-, 2- and 3-folds, respectively), however ghrelin and melanocortin 5 receptor mRNA levels were lower (4- and 2-folds, P = 0.05 and P = 0.03, respectively) in R+ compared to R− animals.We identified several key feeding-related genes that are differently expressed in the hypothalamus of R+ and R− chickens and that might explain the difference in feed intake observed between the two lines.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropeptides - Volume 48, Issue 4, August 2014, Pages 213–220
نویسندگان
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