کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2909937 1174595 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A comparative study to illustrate the benefits of using ethinyl estradiol-cyproterone acetate over metformin in patients with polycystic ovarian syndrome
ترجمه فارسی عنوان
یک مطالعه تطبیقی برای نشان دادن مزایای استفاده از استات استرادیول ـ سیپروترون اتینیل بر متفورمین در بیماران مبتلا به سندرم تخمدان پلی کیستیک
کلمات کلیدی
استات استرادیول ـ سیپروترون اتینیل ؛ متفورمین؛ مقررات متابولیک؛ سندرم تخمدان پلی کیستیک
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

AimThis study was done to illustrate the clinical and biochemical effects of ethinyl estradiol-cyproterone acetate (EE-AC) and metformin in this disease.MethodsThis was a randomized control trial study, done on twenty-six female patients already diagnosed as cases of PCOS. Participants were divided into two study groups: group one (Group 1), received metformin of 500 mg twice daily and the second group (Group 2), was given ethinyl estradiol–cyproterone acetate for 21 consecutive days followed by 7 days drug-free. The course of the treatment for both groups was continued for three consecutive months.ResultsGroup 1 showed a statistical significant increase in serum high density lipoprotein cholesterol (HDL-C) levels (P = 0.006) and a decrease in the level of triglyceride (TG) (P = 0.006). In addition, Group 1 had a significant reduction in the levels of very density lipoprotein cholesterol (VLDL-C) (P = 0.006). Group 2 had a significant increase in serum TG levels (P = 0.01), associated with a significant decrease in serum LDL-C (P = 0.04). Serum testosterone was significantly reduced in group 1 (P = 0.038). This was associated with an improvement in glucose tolerance test (GTT) and BMI in the same group (group 1). Group 2, had an improvement in the menstrual cycle control; hirsutism and acne.ConclusionThis study showed that metformin treatment is beneficial in improving serum lipids; glucose homeostasis and BMI, however, the ethinyl estradiol-cyproterone acetate is superior in improving the clinical manifestation of patients with PCOS, including menstrual cycle regulation, hyperandrogenic state.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diabetes & Metabolic Syndrome: Clinical Research & Reviews - Volume 10, Issue 1, Supplement 1, January–March 2016, Pages S95–S98
نویسندگان
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