کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2928444 1176209 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Repolarization Parameters Are Associated With Mortality In Chagas Disease Patients In The United States
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Repolarization Parameters Are Associated With Mortality In Chagas Disease Patients In The United States
چکیده انگلیسی

ObjectiveThe goal of this study was to examine the association between ECG repolarization parameters and mortality in Chagas disease (CD) patients living in the United States.MethodsCD patients with cardiomyopathy (CM) and bundle branch block (BBB) or BBB alone were compared to age- and sex-matched controls. QT interval, QT dispersion (QTd), T wave peak to T wave end duration (Tp-Te) and T wave peak to T wave end dispersion ((Tp-Te)d) were measured. Presence of fractionated QRS (fQRS) was also assessed. The main outcome measure was the association between ECG parameters and mortality or need for cardiac transplant.ResultsA total of 18 CM and 13 BBB CD patients were studied with 97% originating from Mexico or Central America. QTd (60.0 ± 15.0 ms vs 43.5 ± 9.8 ms, P = 0.0002), Tp-Te (102.6 ± 29.3 ms vs 77.1 ± 11.0 ms, P = 0.0002) and (Tp-Te)d (39.5 ± 9.4 ms vs 22.7 ± 7.6 ms, P < 0.0001) were prolonged in CD CM patients compared to CM controls. Chagas CM patients had more fQRS then controls (84.2 ± 0.10% vs 33.3 ± 0.11%, p = 0.0005). QTd (59.9 ± 15.0 ms vs 29.5 ± 6.9 ms, P = 0.0001) and (Tp-Te)d (40.0 ± 15.9 ms vs 18.5 ± 5.4 ms, p < 0.0001) were longer in the CD BBB group compared to BBB controls. Univariate analysis showed QTd (56.9 ± 15.0 ms vs 46.5 ± 17.3 ms, p = 0.0412) and (Tp-Te)d (36.8 ± 13.5 ms vs 28.5 ± 13.3 ms, p = 0.0395) were associated with death and/or need for cardiac transplant.ConclusionCD patients with CM and BBB or BBB alone have increased evidence of dispersion of repolarization compared to controls. QTd and (Tp-Te)d were associated with increased mortality and/or need for transplant.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Indian Pacing and Electrophysiology Journal - Volume 14, Issue 4, July–August 2014, Pages 171–180
نویسندگان
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