کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
29565 44422 2016 4 صفحه PDF ندارد دانلود رایگان
عنوان انگلیسی مقاله
Phenothiazinium photosensitisers XI. Improved toluidine blue photoantimicrobials
ترجمه فارسی عنوان
خواص ضدمیکروبی تصویری toluidine آبی بهبودیافته Phenothiazinium photosensitisers XI
کلمات کلیدی
آنتی باکتریال؛ ضدقارچ. مواد ضدعفونی کننده؛ Phenothiazinium؛ Photoantimicrobial؛ مشتقات آبی Toluidine
Antibacterial; Antifungal; Disinfectant; Phenothiazinium; Photoantimicrobial; Toluidine blue derivatives
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی


• Novel 2-substituted derivatives of toluidine blue synthesised
• Increased lipophilicities, extended λmax values, lowered aggregation and increased 1O2 yields
• Much improved photoantimicrobial activities relative to the lead compound
• Better antimicrobial performance than standard, conventional drugs and disinfectants

The phenothiazinium derivative toluidine blue O (TBO) is widely employed as a photoantimicrobial agent in clinical trialling, particularly in dentistry. However, its activity against a range of pathogenic microbial species is not significantly different to that of the standard photoantimicrobial methylene blue. In the current study, derivatives of TBO with varying hydrocarbon substitution in chromophore position 2 were synthesised via the established anilinethiosulphonic route, using the mild oxidant silver(II) carbonate to allow substituent preservation.The resulting series of analogues demonstrated the expected increases in visible absorption wavelength and lipophilicity with increasing hydrocarbon content, as well as decreased aggregation for derivatives with bulkier substituents, and all produced singlet oxygen on illumination in vitro. Screening against a range of bacterial and fungal pathogens relevant to infection control showed remarkable increases in activity relative to the parent compound, particularly against the clinically important Gram-negative bacterium Pseudomonas aeruginosa. In addition, in order to demonstrate clinical relevance, the photoactivities of the new derivatives against microbial targets were compared to conventional antibacterial and antifungal drugs, as well as biocides commonly used for local disinfection. Activity here was also generally greater than that of the conventional agents used for comparison, considerably so relative to the local disinfectant agents.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 160, July 2016, Pages 68–71
نویسندگان
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