کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3001769 1180670 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Diet in children with phenylketonuria and risk of cardiovascular disease: A narrative overview
ترجمه فارسی عنوان
رژیم در کودکان مبتلا به فنیل کتونوری و خطر بیماری قلبی عروقی: یک مرور کلی روایت
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی


• The main treatment for phenylketonuria (PKU) is an early phenylalanina-restricted diet.
• This review examine the relationship between PKU diet and the major cardiovascular risk factors in children.
• PKU children compliant with diet seem to display non-different cardiovascular risk compared with the healthy population.

AimsThe aim of this paper is to review the possible relationship of restricted phenylalanine (Phe) diet, a diet primarily comprising low-protein foods and Phe-free protein substitutes, with major cardiovascular risk factors (overweight/obesity, blood lipid profile, plasma levels of homocysteine, adiponectin and free asymmetric dimethylarginine (ADMA), oxidative stress and blood pressure) in PKU children.Data synthesisIn PKU children compliant with diet, blood total cholesterol, low-density lipoprotein cholesterol (LDL-C), plasma ADMA levels and diastolic pressure were reported to be lower and plasma adiponectin levels to be higher compared to healthy controls. No difference was observed in overweight prevalence and in high-density lipoprotein cholesterol (HDL-C) levels. Inconsistent results were found for plasma homocysteine levels and antioxidant status.ConclusionsPKU children compliant with diet seem to display non-different cardiovascular risks compared with the healthy population. Well-designed longitudinal studies are required to clarify the potential underlying mechanisms associated with PKU and cardiovascular risk factors.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition, Metabolism and Cardiovascular Diseases - Volume 26, Issue 3, March 2016, Pages 171–177
نویسندگان
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