کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3036472 1184371 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Potential risk factors for dexmedetomidine withdrawal seizures in infants after surgery for congenital heart disease
ترجمه فارسی عنوان
عوامل خطر بالقوه برای تشنج خروج دکستومیدیدین در نوزادان پس از جراحی برای بیماری های مادرزادی قلبی
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب تکاملی
چکیده انگلیسی

PurposeFew studies are available on withdrawal seizures about dexmedetomidine (DEX). Thus, we retrospectively evaluated the incidence of withdrawal seizures after discontinuation of DEX and examined potential risk factors in infants after cardiovascular surgery.MethodsThe medical records of 142 infants who had undergone cardiovascular surgery between April 2010 and November 2013 were examined. Clinical characteristics and usage of DEX were analyzed. DEX withdrawal seizures were evaluated using Withdrawal Assessment Tool – version 1 (WAT-1). All the patients and controls were categorized according to DEX discontinuation strategy, which was either gradual or abrupt.ResultsNine patients (6.3%) developed generalized clonic or generalized tonic–clonic seizures accompanied by preceding fever of >38 °C approximately four to eight hours following the discontinuation of DEX, and were clinically diagnosed as DEX withdrawal seizures with a median WAT-1 score of 3. Clinical characteristics and operative data were similar, but median cumulative dose and maximum temperature after discontinuation of DEX were significantly higher in infants with withdrawal seizures than in those without (P = 0.007 and P < 0.001, respectively). Eight of the 9 patients with withdrawal seizures (88.9%) and 20 of the 133 patients (15.0%) with no withdrawal seizures had discontinued DEX abruptly (P < 0.001). Cumulative dose and abrupt discontinuation of DEX were significantly associated with DEX withdrawal seizures in infants after cardiovascular surgery (R = 0.619, P = 0.004).ConclusionsPhysicians should be aware that infants who received DEX after cardiovascular surgery had potential to cause withdrawal seizures accompanied by preceding pyrexia after discontinuation of DEX. Higher cumulative dose and abrupt discontinuation of DEX appears to increase the risk for these withdrawal seizures.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain and Development - Volume 38, Issue 7, August 2016, Pages 648–653
نویسندگان
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