کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3039545 1579680 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Long-term outcomes following Gamma Knife radiosurgery for small, newly diagnosed meningiomas
ترجمه فارسی عنوان
نتایج بلندمدت پس از جراحی رادیواکتیو گاما چاق برای مننژیم های کوچک و جدید تشخیص داده شده
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


• A rare study for investigating the results of GKRS for small-sized meningioma.
• The natural history and outcome of GKRS of small-sized meningioma were reviewed.
• Highlighted the importance of histology in GKRS outcome of small-sized meningioma.

ObjectAlthough stereotactic radiosurgery were established as an effective treatment modality for intracranial meningiomas, there have been no comprehensive studies focused on long-term outcomes and histologic results for purely small-sized meningiomas after radiosurgery. Therefore, we investigated long-term outcomes and histology of small-sized meningiomas after radiosurgery.MethodsThe authors reviewed the data retrospectively of a total of 920 patients treated with single-session Gamma Knife radiosurgery with intracranial meningioma (Radiosurgery center, Asan Medical Center). After stratifying meningiomas by size, it was defined as small-sized meningiomas less than 1000 mm3 in tumor volume. The patients with newly diagnosed small-sized meningiomas were enrolled in this study (113 patients). All patients had a minimum follow up of 12 months (12–120 months), clinical symptoms and brain MRI were checked by neurosurgeons. When the tumors grew readily with newly developed neurologic symptoms, microsurgical resection was performed. Histologic analysis was done with resected tumors by neuropathologists.ResultsAmong 113 patients, 9 patients (7.9%) showed the increased tumors with clinical symptoms after radiosurgery, followed by microsurgical resection in 4 patients (3.5%). The other 5 (4.4%) patients showed that the size of tumor slightly increased after GKRS that is transient. Interestingly, the histologic results of resected meningiomas due to increased volume after radiosurgery were all revealed as WHO grade II meningiomas (1 clear cell type and 3 atypical meningiomas). Although the histologic confirmation was performed only in 4 patients underwent surgery, it is interesting that all tumors readily grew after radiosurgery were high grade meningiomas.ConclusionIn this study, we revealed the long-term outcomes of small meningiomas following stereotactic radiosurgery in the aspect of tumor control. The tumor control rate of radiosurgery in small meningiomas reached to 92.1% and there were perilesional edema in 6.1%. The 7.9% of tumors grew readily and 3.5% were finally underwent microsurgical resection. The histologic results were all WHO grade II meningiomas (1 clear cell and 3 atypical meningiomas).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurology and Neurosurgery - Volume 142, March 2016, Pages 1–7
نویسندگان
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