کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3042745 1184958 2016 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ERP C250 shows the elderly (cognitively normal, Alzheimer’s disease) store more stimuli in short-term memory than Young Adults do
ترجمه فارسی عنوان
ERP C250 نشان می دهد سالمندان (شناختی طبیعی، بیماری آلزایمر) محرک های بیشتری را در حافظه کوتاه مدت ذخیره می کنند تا نوجوانان
کلمات کلیدی
پتانسیل های مربوط به رویداد (ERP)؛ الکتروفیزیولوژی؛ بیماری آلزایمر (AD)؛ حافظه کوتاه مدت؛ تجزیه و تحلیل اجزای اصلی (PCA)؛ جزء کوتاهمدت ERP C250
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


• In Young Adults, ERP C250 is more positive when stimuli that need to be later recalled are stored in short-term memory.
• Normal Elderly show similar C250 activation, as well as to other stimuli.
• Alzheimer’s disease subjects are similar to Normal Elderly, except for a “slow start” trial-wise.

ObjectiveTo determine how aging and dementia affect the brain’s initial storing of task-relevant and irrelevant information in short-term memory.MethodsWe used brain Event-Related Potentials (ERPs) to measure short-term memory storage (ERP component C250) in 36 Young Adults, 36 Normal Elderly, and 36 early-stage AD subjects. Participants performed the Number–Letter task, a cognitive paradigm requiring memory storage of a first relevant stimulus to compare it with a second stimulus.ResultsIn Young Adults, C250 was more positive for the first task-relevant stimulus compared to all other stimuli. C250 in Normal Elderly and AD subjects was roughly the same to relevant and irrelevant stimuli in Intratrial Parts 1–3 but not 4. The AD group had lower C250 to relevant stimuli in part 1.ConclusionsBoth normal aging and dementia cause less differentiation of relevant from irrelevant information in initial storage. There was a large aging effect involving differences in the pattern of C250 responses of the Young Adult versus the Normal Elderly/AD groups. Also, a potential dementia effect was obtained.SignificanceC250 is a candidate tool for measuring short-term memory performance on a biological level, as well as a potential marker for memory changes due to normal aging and dementia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurophysiology - Volume 127, Issue 6, June 2016, Pages 2423–2435
نویسندگان
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