کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3053469 1580005 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The association between antioxidant enzyme polymorphisms and cerebral palsy after perinatal hypoxic-ischaemic encephalopathy
ترجمه فارسی عنوان
ارتباط بین پلی مورفیسم های آنزیم آنتی اکسیدان و فلج مغزی بعد از پری ناتال انسفالوپاتی هیپوکسیک ـ ایسکمیک
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب تکاملی
چکیده انگلیسی


• ROS formation during perinatal hypoxia may lead to neurological sequelae.
• We investigated polymorphisms in antioxidant genes in children with HIE.
• No association was found between SOD2 and GPX1 polymorphisms and the risk of CP.
• Carriers of CAT rs1001179 polymorphism had increased susceptibility of CP after HIE.

BackgroundHypoxic-ischaemic perinatal brain injury leads to the formation of reactive oxygen species (ROS) and the resultant cell and tissue damage may cause neurological sequelae such as cerebral palsy and/or epilepsy. A decrease in the capacity for defending against ROS may increase the susceptibility to cerebral palsy. The aim of this study was to investigate the impact of common functional polymorphisms in the antioxidant genes SOD2, GPX1 and CAT, associated with a decreased capacity for defending against ROS, in patients with perinatal hypoxic-ischaemic encephalopathy (HIE).Methods80 patients previously diagnosed with perinatal HIE were included. Genomic DNA was isolated from buccal swabs and genotyped for SOD2 rs4880, GPX1 rs1050450 and CAT rs1001179 using real-time PCR-based methods.ResultsAmong patients with neonatal HIE, carriers of at least one polymorphic CAT rs1001179 T allele were significantly associated with development of cerebral palsy compared to non-carriers (univariate logistic regression, p = 0.026; OR = 3.36; 95% CI = 1.16–9.76). This difference remained statistically significant after accounting for prematurity. The investigated SOD2 and GPX1 polymorphisms were not associated with cerebral palsy after perinatal HIE.ConclusionCAT rs1001179 polymorphism could be used to identify children that have a higher susceptibility to cerebral palsy after perinatal HIE.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Paediatric Neurology - Volume 20, Issue 5, September 2016, Pages 704–708
نویسندگان
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